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Lyme disease, a tick-borne infection caused by the spirochete Borrelia burgdorferi, involves many organ systems. Three clinical stages of involvement have been described; patients with the
disease may have cutaneous, arthritic, neurologic, or cardiac symptoms, or a constellation of manifestations. Specific antibody testing and antibiotic agents are available for
Lyme disease, but a high index of suspicion must be exercised to recognize atypical manifestations.