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Lyme borreliosis is a spirochetal infection with a potential to produce a clinical
disease in the human host with protean manifestations as diverse as the spectrum of
disease caused by Treponema pallidum. Neuro-ophthalmologic manifestations of
Lyme borreliosis are emphasized in this short review. A brief historical chronicle of
Lyme disease is offered. Potential pitfalls in the diagnosis of
Lyme disease with an emphasis on false negative serology and currently available diagnostic modalities are presented. Therapeutic options for
Lyme borreliosis are briefly reviewed.