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Lyme meningoencephalitis: report of a severe, penicillin-resistant case.

Abstract

Although
Lyme disease frequently attacks the central nervous system, this involvement is rarely severe, and high-dose intravenous penicillin usually is adequate treatment. The patient we describe developed severe
Lyme meningoencephalitis despite receiving a full course of penicillin, and his condition continued to deteriorate after reinstitution of this treatment. Intravenous chloramphenicol was used successfully and resulted in a substantial improvement.

Arthritis Rheum. 1987 Jun;30(6):705-8. Case Reports [1]