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Lyme neuroborreliosis in the rhesus monkey.

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Although there are several animal models of
Lyme disease, only the rhesus monkey model exhibits all of the key manifestations of the
disease. After infection with Borrelia burgdorferi, rhesus monkeys develop signs of early localized, early disseminated, and chronic
Lyme disease. Specific features include erythema migrans, uveitis, myocarditis, arthritis, and
disease of the peripheral and central nervous system. One of the unique features of the rhesus monkey model is the development of
Lyme neuroborreliosis. Peripheral nervous system (PNS) involvement is usually in the form of a mononeuropathy multiplex with primarily axonal-loss features. Evidence of central nervous system (CNS)
disease has included CSF pleocytosis, meningeal inflammation, spinal cord lesions, and polymerase chain reaction (PCR) data consistent with chronic CNS infection. The pathogenesis of
Lyme neuroborreliosis is not well understood, but it is likely to involve complex interactions between B. burgdorferi and host immune mechanisms.

Semin Neurol. 1997 Mar;17(1):53-6. Research Support, U.S. Gov’t, P.H.S.; Review

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