Get FREE U.S. Shipping on $75 Orders*

Lymphoproliferative responses to Borrelia burgdorferi in Lyme disease.

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading...

Abstract

OBJECTIVE:

To compare lymphocyte proliferative responses to Borrelia burgdorferi in healthy controls and patients with
Lyme disease.

PATIENTS:

Twelve patients fulfilling case-definition criteria for
Lyme disease. Twelve healthy volunteers and two newborns served as controls.

MEASUREMENTS:

Antibodies to B. burgdorferi were measured by enzyme-linked immunosorbent assay (ELISA). Proliferation of peripheral blood lymphocytes cultured for 5 days with B. burgdorferi, recall antigens, or pokeweed mitogen was measured by radioactive thymidine uptake.

RESULTS:

Lymphocytes from 11 patients with
Lyme disease, 8 healthy seronegative controls, and two newborns showed elevated responses when stimulated with B. burgdorferi. When a patient and a control were studied on the same day, the patient’s lymphocyte response to B. burgdorferi exceeded the control’s in only 5 of 12 cases. Lymphocytes from both patients and controls responded to B. burgdorferi isolates from three different sources.

CONCLUSIONS:

Heightened lymphocyte responses to B. burgdorferi are found in patients with
Lyme disease but elevated responses also frequently occur in healthy controls. At present, the interpretation of a positive lymphocyte response to B. burgdorferi would be difficult in ambiguous clinical situations.

Ann Intern Med. 1991 Feb 15;114(4):285-9. Clinical Trial; Research Support, U.S. Gov’t, P.H.S.

ProHealth CBD Store

 

Are you vitamin d deficient?

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading...



Leave a Reply