10% Off $75 Orders! Use Code SAVE10P Shop Now
One use per customer. Not available with Autoship. Expires 5/28/18.

ME and CFS: The essence of objective assessment, accurate diagnosis, and acknowledging biological and clinical subgroups

1 Star2 Stars3 Stars4 Stars5 Stars (12 votes, average: 3.75 out of 5)
Loading...

Note: The doi number for this article has been incorrectly entered by the publisher. If you click on the journal (in “Source”) you will be taken to another article by the same author. This is an error that can only be corrected by the editors of the journal.

By Frank N. Twisk

Abstract

Myalgic Encephalomyelitis (ME) was identified as a new clinical entity in 1959 and has been acknowledged as a disease of the central nervous system/neurological disease by the World Health Organisation since 1969. Cognitive impairment, (muscle) weakness, circulatory disturbances, marked variability of symptoms, and, above all, post-exertional malaise: a long-lasting increase of symptoms after minor exertion, are distinctive symptoms of ME.

Chronic Fatigue Syndrome (CFS) was introduced in 1988 and was redefined into clinically evaluated, unexplained (persistent or relapsing) chronic fatigue, accompanied by at least four out of a list of eight symptoms, e.g. headaches and unrefreshing sleep, in 1994.

Although the labels are used interchangeably, ME and CFS define distinct diagnostic entities. Post-exertional malaise and cognitive deficits e.g. are not mandatory for the diagnosis CFS, while obligatory for the diagnosis ME. “Fatigue” is not obligatory for the diagnosis ME.

Since fatigue and other symptoms are subjective and ambiguous, research has been hampered. Despite this and other methodological issues, research has observed specific abnormalities in ME/CFS repetitively, e.g. immunological abnormalities, oxidative and nitrosative.

Citation: Twisk FN (2014). Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS): The essence of objective assessment, accurate diagnosis, and acknowledging biological and clinical subgroups. Front. Physiol. 5:109. doi: 10.3389/fphys.2014.00109

1 Star2 Stars3 Stars4 Stars5 Stars (12 votes, average: 3.75 out of 5)
Loading...



2 thoughts on “ME and CFS: The essence of objective assessment, accurate diagnosis, and acknowledging biological and clinical subgroups”

  1. sPeeDeeBee says:

    This surely sounds like a great commentary article to have, so I went to the source. When I requested the full article, what came up has an abstract very unlike the one you’ve printed here. Just wondering how that happened…

  2. franktwisk says:

    You can download the PDF of the manuscript and the appendix here:
    http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00109/full

Leave a Reply