Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): A voxel-based morphometry 3-T MRI study
– Source: British Journal of Radiology, Nov 29, 2011
By Basant K Puri, et al.
[Note: With regard to the suggestion of subtle visual abnormalties, see “UK Study of Visual Function in ME/CFS Announced,” posted Nov 28, 2011.]
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Objective: It is not established whether myalgic encephalomyelitis / chronic fatigue syndrome (CFS) is associated with structural brain changes. The aim of this study was to investigate this by conducting the largest voxel-based morphometry study to date in CFS.
Methods: High-resolution structural 3-T cerebral MRI scanning was carried out in 26 CFS patients and 26 age- and gender-matched healthy volunteers. Voxel-wise generalized linear modeling was applied to the processed MR data using permutation-based non-parametric testing, forming clusters at t > 2.3 and testing clusters for significance at p
Results: Significant voxels (p Conclusion:
These data support the hypothesis that:
• Significant neuroanatomical changes occur in CFS,
• And are consistent with the complaint of impaired memory that is common in this illness.
They also suggest that subtle abnormalities in visual processing, and discrepancies between intended actions and consequent movements, may occur in CFS.
Source: British Journal of Radiology, Nov 29, 2011. DOI:10.1259/bjr/93889091, by Puri BK, Jakeman PM, Agour M, Gunatilake KDR, Fernando KAC, Gurusinghe AI, Treasaden IH, Waldman AD, Gishen P. Department of Imaging, Hammersmith Hospital, London, UK; Department of Physical Education and Sport Sciences, University of Limerick, Republic of Ireland; University of Hertfordshire, and Care Principles, Rose Lodge, Langley, West Midlands, UK; The Ridge Hill Centre, Dudley, UK; Brooklands Hospital, Birmingham, West Midlands, UK; Broadmoor Hospital, Berkshire, UK; Three Bridges Unit, WLMHT, Middlesex, UK; National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.