Mechanisms of Disease: Genetics of Fibromyalgia

Journal: Nature Clinical Practice Rheumatology. 2006 Dec;2(12):671-8. Authors and affiliations: Ablin JN, Cohen H, Buskila D. Department of Rheumatology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Israel. PMID: 17133252

Fibromyalgia is characterized by widespread pain and tenderness, and has a significant familial component. The etiology of Fibromyalgia remains unclear, but genetic factors seem to have a significant role, and are influenced by environmental factors.

Research over the past two decades has demonstrated that genetic polymorphisms in the serotoninergic, dopaminergic, and catecholaminergic systems of pain transmission and processing are involved in the etiology of Fibromyalgia, but additional candidates continue to emerge.

Fibromyalgia is thought to belong to the group of affective spectrum disorders, which include related psychiatric and medical disorders. As the concept of affective spectrum disorders continues to evolve, progress in the understanding of the genetic basis of related functional disorders, such as irritable bowel syndrome and post-traumatic-stress disorder, is aiding our understanding of the genetic basis of Fibromyalgia.

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