Meta-analysis finds dose-response relationship between increased magnesium intake and lower diabetes risk


Reprinted with the kind permission of Life Extension.

December 5 2016. The results of a systematic review and meta-analysis reported in Nutrients on November 19, 2016 found an association between increasing magnesium intake levels and a lower risk of type 2 diabetes.

Xin Fang of the Karolinska Intitutet in Stockholm and colleagues selected 25 studies involving a total of 637,922 subjects for their analysis. Dietary questionnaire responses were analyzed for the amount of magnesium consumed. Magnesium intake ranged from a median of 115 milligrams per day in African American women to 478 milligrams per day in a U.S. population. Over 4.6 to 20 years of follow-up, 26,828 cases of type 2 diabetes were diagnosed.

In comparison with the lowest magnesium consumption group in the meta-analysis population, men whose intake was higher had a 16% lower risk of developing diabetes and women had a 19% lower risk. For each 100 milligram per day increase in magnesium intake, the adjusted risk of type 2 diabetes was reduced by 8 to 13%.

“To our knowledge, this study is the largest meta-analysis that investigated the dose-response relationship between dietary magnesium intake and type 2 diabetes risk,” the authors announce.

“The combined data supports a role for magnesium in reducing risk of type 2 diabetes, with a statistically significant linear dose-response pattern within the reference dose range of dietary intake among Asian and US populations,” they conclude. “The evidence from Europe and black people is limited and more prospective studies are needed for the two subgroups.”

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