Reprinted with the kind permission of Life Extension.
April 19 2017. The results of a meta-analysis reported on February 16, 2017 in PLOS One affirmed a relationship between deficient serum 25-hydroxyvitamin D levels and a greater risk of all-cause mortality during a median period of 10.5 years.
“Our work is the first meta-analysis using standardized 25(OH)D data and a one-step procedure for statistical analyses, in which data from each individual participant was used to calculate the regression curve for the 25(OH)D and mortality relationship,” authors Martin Gaksch and colleagues announce.
The analysis included a total of 26,916 participants from eight prospective studies that included seven general population cohorts. Dr Gaksch and colleagues utilized Vitamin D Standardization Program (established by The National Institutes of Health Office of Dietary Supplements) protocols to analyze participants’ serum levels of vitamin D.
Over a 10.5 year median, 6,802 deaths occurred. Among participants whose 25-hydroxyvitamin D levels were 16-20 nanograms per milliliter (ng/mL) to 20 ng/mL, there was a 15% greater risk of dying from any cause in comparison with the risk experienced by those whose levels were 30-40 ng/mL. While having a vitamin D level of 12-16 ng/mL was associated with a 33% greater risk of mortality, vitamin D levels of less than 12 ng/mL were associated with a 67% increase. Similar results were obtained when cardiovascular disease mortality was separately evaluated. Higher vitamin D levels of up to 50 ng/mL were not associated with any increase in mortality risk.
“Based on our results, we believe that the final answer on potential survival benefits of vitamin D should be derived from randomized controlled trials in severely vitamin D deficient individuals,” the authors conclude. “These randomized controlled trials are urgently needed because vitamin D deficiency and its diagnosis and treatment are important public health issues.”