Migraine in women with chronic pelvic pain with and without endometriosis – Source: Fertility and Sterility, Dec 8, 2010

Objective: To examine the prevalence of migraine in women with chronic pelvic pain with and without endometriosis.

Design: Prospective study of headache, pelvic pain, and quality of life before laparoscopic surgery for pelvic pain. Endometriosis was diagnosed pathologically. Headaches were classified as migraine or non-migraine using International Headache Society criteria.

Setting: Clinical research hospital.

Patient(s): 108 women in a clinical trial for chronic pelvic pain (Trial ID NCT00001848).

Intervention(s): Laparoscopy to diagnose endometriosis, assessment by neurologist to assess headaches.

Main Outcome Measure(s): Prevalence of migraine and other headaches in women with chronic pelvic pain with or without endometriosis. Headache frequency, severity and relationship to pelvic pain and endometriosis.

Result(s):

• Lifetime prevalence of definite or possible migraine was 67% of women with chronic pelvic pain.

• An additional 8% met criteria for possible migraine [75% total].

• Migraine was no more likely in women with endometriosis than those without.

• Women with the most severe headaches had a lower quality of life compared with those with pelvic pain alone.

Conclusion(s):

• Migraine headache is common in women with chronic pelvic pain, regardless of endometriosis,

• And contributes to disability in those with both conditions.

The strong association suggests a common pathophysiology. [bolding added]

Source: Fertility and Sterility, Dec 8, 2010. PMID: 21145540, by Karp BI, Sinaii N, Nieman LK, Silberstein SD, Stratton P. National Institute of Neurological disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Thomas Jefferson University, Philadelphia, Pennsylvania, USA. [Email: ps79c@nih.gov]

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