Reprinted with the kind permission of Life Extension.
July 14 2017. Readers of What’s Hot may recall the publication of the recent finding of Mayo Clinic researchers of a potential antiaging senolytic effect for fisetin, a compound found in plants that is available as a dietary supplement. On June 2, 2017 in The Journals of Gerontology Series A, researchers from the Salk Institute reported a reduction in aging-related inflammation and cognitive decline in mice given fisetin.
Acting on earlier findings of a decrease in memory loss in association with fisetin supplementation in mice that were genetically modified to develop Alzheimer’s disease, Pamela Maher and colleagues tested the compound in a SAMP8 mouse model of premature aging. Three-month-old animals were given diets with or without fisetin for 7 months, during which memory and activity tests were conducted, and levels of proteins related to brain function and responses to inflammation and stress were measured.
“At 10 months, the differences between these two groups were striking,” reported Dr Maher, who is a senior staff scientist in Salk’s Cellular Neurobiology Laboratory. While mice that did not receive fisetin did poorly in tests of cognitive function and had elevated markers of stress and inflammation, those that received the compound were not noticeably different from untreated 3-month-old SAMP8 mice.
“Mice are not people, of course,” noted Dr Maher, “But there are enough similarities that we think fisetin warrants a closer look, not only for potentially treating sporadic Alzheimer’s disease but also for reducing some of the cognitive effects associated with aging, generally.”
“Companies have put fisetin into various health products but there hasn’t been enough serious testing of the compound,” she added. “Based on our ongoing work, we think fisetin might be helpful as a preventative for many age-associated neurodegenerative diseases, not just Alzheimer’s, and we’d like to encourage more rigorous study of it.”