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More specific bands in the IgG western blot in sera from Scottish patients with suspected Lyme borreliosis.

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Abstract

AIMS:

To identify further Western blot bands that may be specific in the diagnosis of
Lyme borreliosis.

METHODS:

The Borrelia burgdorferi antibody profiles of 270 western blot positive patients and 241 western blot negative patients from 2008 were examined.

RESULTS:

27 different non-specific bands were detected in both groups. Six of 27 (22%) of the non-specific bands were detected significantly more in the western blot positive patients compared to the western blot negative patients (20 kDa, p<0.0001; 28 kDa, p<0.002; 36 kDa, p<0.002; 37 kDa, p<0.007; 48 kDa, p<0.023; 56 kDa, p<0.028; two-tailed F test).

CONCLUSION:

Results suggest that the 20, 28 and 48 kDa bands should be regarded as specific.

J Clin Pathol. 2010 Aug;63(8):719-21. doi: 10.1136/jcp.2010.076307. Epub 2010 Jun 30. Review

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