Morphologic aspects of fibromyalgia (FM)

The most common morphological finding in muscle biopsis in

longstanding fibromyalgia is type II fiber atrophy. This can

be found in many other conditions such as disuse atrophy,

affections of the corticospinal tracts, steroid atrophy, and

other different neuromuscular disorders. An increase in lipid

droplets and a slight proliferation of mitochondria in type I

muscle fibers are correlated with the duration of

fibromyalgia. In some cases we could find some ragged red

fibers (RRF) which histochemically show a pronounced

accumulation of lipids and mitochondria and single fiber

defects of cytochrome-c-oxidase. In some fibromyalgia patients

with RRF, we could find deletions of the mitochondrial genoma.

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