Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: A systematic review – Source: Journal of Gastroenterology, Feb 18, 2011

Background: The causes of irritable bowel syndrome (IBS) remain obscure. Some investigators have proposed chronic low-grade mucosal inflammation as a potential etiological factor. We performed a systematic review to examine this issue in detail.

Methods: MEDLINE, EMBASE, and EMBASE classic were searched up to December 2010 to identify studies of case-control design applying tests for low-grade inflammation to either full-thickness intestinal or endoscopic mucosal biopsies from patients with IBS.

Controls were required to be healthy individuals, or asymptomatic patients undergoing investigation for reasons other than the reporting of upper or lower gastrointestinal symptoms. Individual study results were summarized descriptively.

Results: The literature search identified 1,388 citations, of which 16 studies were eligible for inclusion. Individual study results were diverse, partly as a consequence of the different surrogate markers for inflammatory mechanisms studied. Mast cells, T lymphocytes, B lymphocytes, and mucosal cytokine production all appeared altered among cases with IBS in individual studies, while no study demonstrated a significant difference in numbers of plasma cells, neutrophils, or eosinophils.

Some studies suggested a relationship between mast cell abnormalities and symptom severity and frequency, as well as co-existent fatigue and depression. [Note: mast cells are white blood cells that play a role in the immune system. When stimulated they release chemicals that signal infection or injury and cause an inflammation in the area.]

Studies were limited by the lack of comparability of controls, and the fact that most were conducted in highly selected groups of patients with IBS.

Low-grade mucosal inflammation, particularly mast cell activation, may be a contributory factor in the pathogenesis of IBS.

Mast cell stabilizers warrant further assessment as a potential therapy in the condition. [Note: Mast cell stabilizers are used, for example, to keep mast cells from releasing the chemicals that cause inflammation – e.g., release of histamine in some allergic disorders.]

Source: Journal of Gastroenterology, Feb 18, 2011.  PMID: 21331765, by Ford AC, Talley NJ. Leeds Gastroenterology InstituteLeeds General Infirmary, Great George Street, Leeds, UK, [Email:]

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