Muscle function & origin of pain in fibromyalgia (FM)

It may be concluded that both peripheral and central
mechanisms may operate in the pathophysiology of both impaired
muscle function and pain in FM. These mechanisms may in part
be attributable to physical deconditioning and disuse of
muscle secondary to the characteristic pain and fatigue so
often seen in FM. Most likely the initiation of this condition
is multifactorial and the combination of peripheral and
central factors that constitute a vicious circle may
perpetuate the condition into a chronic state.

Bennett RM, Jacobsen S

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