Following observation of fatigue syndromes in people who have been
occupationally exposed to pesticides and insecticides which
exert their toxicity through the GABAa receptor, we have
formulated the hypothesis that fatigue syndromes in general
may be secondary to altered sensitivity of the GABAa receptor.
We discuss the possible involvement of organochlorine
compounds which are widespread in the environment.
Organophosphate compounds may have similar toxic effects
through damaged cholinergic input to the dentate gyrus of the
hippocampus where cholinergic and GABAergic transmission are
Corrigan FM, MacDonald S, Brown A, Armstrong K, Armstrong EM