1. Chronic fatigue syndrome (CFS) is characterized by a new onset of
significant fatigue for a period of six months or longer
usually following an infection, injury or period of high
2. The exact etiology of CFS is not known and a
diagnostic test is not available. Hence, the diagnosis is
made by exclusion of other explanations for the patient’s
symptoms and by meeting the CDC research case definitions.
Early studies supported an infectious or immune dysregulation
hypothesis for the pathophysiology of CFS.
studies documented that neurological, affective and cognitive
symptoms also occur at high rates in CFS patients.
Neuropsychological, neuroendocrine studies and brain imaging
have now confirmed the occurrence of neurobiological
abnormalities in most patients with CFS.
4. In this article,
the authors review these findings in relation to the clinical
neurobiology of CFS and their potential relevance to
Gonzalez MB, Cousins JC, Doraiswamy PM