Neurochemical pathogenesis of fibromyalgia (FM)

In contrast with the situation just a few years ago, the most

widely accepted model for the pathogenesis of FMS now invokes

CNS mechanisms like nociception and allodynia rather than

pathologically painful muscles. The levels of platelet

serotonin and CSF substance P appear to be abnormal in

directions that could logically amplify pain perception. The

extent to which these mechanisms are unique to FMS will be

critical in determining the direction that future research

should take. Certainly, a better understanding of the cause of

FMS could represent an important step toward the development

of more effective therapy.

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