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Neuropsychological functioning in chronic Lyme disease.


Lyme disease is currently the most common vector-borne illness in the United States. The
disease is multisystemic, and chronic
disease, in particular, may be associated with neuropsychological deficits. However, to date, only a few empirical studies exist, which examine the neuropsychological sequelae associated with chronic
Lyme disease. A review of the literature shows that the deficits observed in adults with chronic
Lyme disease are generally consistent with the deficits that can be seen in processes with primarily frontal systems involvement. These observations are generally consistent with neuroradiologic findings. The clinical presentation in chronic
Lyme disease and the nature of the neuropsychological deficits are discussed, as are several central issues in understanding neuropsychological functioning in chronic
Lyme disease, such as the impact of chronic illness, response to treatment, and the relationship between neuropsychological performance and depression, fatigue, and neurological indicators of

Neuropsychol Rev. 2002 Sep;12(3):153-77. Review [1]