Neuropsychology of Chronic Fatigue Syndrome (CFS): a critical review

This article provides a comprehensive and critical review of

the neuropsychological and related literature on chronic

fatigue syndrome (CFS). Despite the methodological limitations

observed in several studies, some consistent findings are

noted. The most consistently documented neuropsychological

impairments are in the areas of complex information processing

speed and efficiency. General intellectual abilities and

higher order cognitive skills are intact. Emotional factors

influence subjective report of cognitive difficulty, whereas

their effect on objective performance remains uncertain.

Although the neuropathological processes underlying cognitive

dysfunction in CFS are not yet known, preliminary evidence

suggests the involvement of cerebral white matter. Directions

for future research are outlined.

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