No findings of enteroviruses in Swedish patients with Chronic Fatigue Syndrome (CFS)

Enteroviruses have been proposed to cause an immune complex

disease in the chronic fatigue syndrome. Altogether 34

patients with the chronic fatigue syndrome, according to

criteria of the Centers for Disease Control, USA, were

studied evenly over the seasons for the possible presence of

a chronic enterovirus infection. In 11 patients, 1-5 faecal

samples were collected at about 6 month intervals for virus

isolation before and after acid treatment, followed by

ultracetrifugation at pH 3 to dissolve possible

enterovirus-antibody complexes. Another 14 fecal samples were

subjected to routine virus isolation alone. Seven pairs of

serum-cerebrospinal fluid samples were analysed for

cross-reactive IgG antibody activity to enteroviruses. In 29

patients a muscle biopsy was collected for enterovirus

polymerase chain reaction (PCR). We were unable to identify

enteroviruses in any of these samples by any of these

techniques. Our study does not confirm evidence for

persistent enterovirus infection in the chronic fatigue


Lindh G, Samuelson A, Hedlund KO, Eveng~ard B, Lindquist L, Ehrnst A

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