Persistent pain is often difficult to understand and to treat.
Clinical and neurophysiological evidence is offered,
suggesting that this often occurs because persistent pain is
partially or wholly of non-nociceptive afferent origin. The
concept of non-nociceptive pain and the potential roles of
proprioceptive afferents in the production of non-nociceptive
pain are particularly emphasized. It is suggested that
non-nociceptive pain is often an important component of pain
associated with peripheral and central neuropathy,
fibromyalgia, trauma-induced pain, idiopathic low back pain,
and chronic regional pain syndrome. Non-nociceptive pain is
often dependent upon central sensitization induced by prior
or ongoing nociception. Therapeutic methods which minimize
nociceptive afferent activity are important in the prevention
and/or elimination of often intractable non-nociceptive pain.
Kramis RC, Roberts WJ, Gillette RG