Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with Fibromyalgia Syndrome

Journal: Sleep Medicine. 2007 Mar 16; [E-publication ahead of print]

Authors and Affiliations: Taiwo OB, Russell IJ, Mignot E, Lin L, Michalek JE, Haynes W, Xiao Y, Zeitzer JM, Larson AA. University of Minnesota, Department of Veterinary and Biomedical Sciences, St. Paul, Minnesota, USA.

PMID: 17369087

Background: The hypothalamic neuropeptide hypocretin (orexin) modulates sleep-wake, feeding and endocrine functions. Cerebrospinal fluid (CSF)hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence [extreme sleepiness] and rapid eye movement (REM) sleep abnormalities.

Methods: We determined CSF Hcrt-1 concentrations of patients with the Fibromyalgia Syndrome (FMS), a condition characterized by fatigue, insomnia, and in some cases daytime hypersomnolence.

Conclusions: These findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.

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