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Normal melatonin levels in patients with fibromyalgia (FM) syndrome

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OBJECTIVE: To assess urine levels of melatonin measured by 6-

sulphatoxymelatonin (aMT6s) in patients with fibromyalgia

(FM).

METHODS: Nocturnal aMT6s urine levels were measured by

ELISA, in a sample of urine collected from 10 PM to 7 AM from

39 female patients with FM and 39 age matched healthy female

controls. All subjects were interviewed and assessed for

nonarticular tenderness, FM symptoms, quality of life, and

physical functioning.

RESULTS: Nocturnal aMT6s levels of

patients with FM were not statistically different from those

of controls: 16.7+/-9.2 vs 16.0+/-11.3 microg, respectively.

No association was observed between aMT6s levels of patients

with FM and disease duration, reproductive status, sleep and

mood disturbances.

CONCLUSION: Nocturnal urine aMT6s levels

were similar in patients with FM and controls. Studies are

needed to elucidate the possible role of melatonin in FM and

should include larger samples of newly diagnosed untreated

patients with FM.

1 Star2 Stars3 Stars4 Stars5 Stars (103 votes, average: 2.95 out of 5)
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