Omega-3 fatty acids for cardiovascular disease prevention – Source: Current Treatment Options in Cardiovascular Medicine, Aug 2010

Opinion Statement:
Major dietary sources of omega-3 fatty acids are fish containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as nuts, seeds, and vegetable oils containing alpha-linolenic acid (ALA) [type of omega-3 derived from plant sources such as flaxseed oil].

Omega-3 fatty acids, especially those derived from marine sources, may be a useful tool for the primary and secondary prevention of cardiovascular disease.

Omega-3s exert their cardioprotective effects through multiple mechanisms, including reducing arrhythmias and altering production of prostaglandins, which reduces inflammation and improves platelet and endothelial function.

To date, no serious adverse effects of omega-3s have been identified, despite extensive study.

In adults, any potential harm from mercury exposure from consuming fish rich in omega-3s is outweighed by the proven cardiovascular benefits of eating fish.

Concerns over increased bleeding complications have not materialized despite the increased concomitant use of aspirin and clopidogrel.

• We recommend one serving (200-400 g) of fatty fish two times per week and a diet that includes foods rich in ALA for the primary prevention of cardiovascular disease.

• We recommend one serving (200-400 g) of fatty fish or a fish oil supplement containing 900 mg of EPA + DHA every day and a diet rich in ALA for patients with known cardiovascular disease or congestive heart failure.

Source: Current Treatment Options in Cardiovascular Medicine, Aug 2010; 12(4):365-80. PMID: 20842560, by Defilippis AP, Blaha MJ, Jacobson TA. Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, USA. [Email:]

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