P300 assessment of Chronic Fatigue Syndrome (CFS)

The P3(00) event-related brain potential (ERP) was elicited with an
auditory tone-discrimination paradigm in 25 patients diagnosed
with chronic fatigue syndrome (CFS) and 25 matched normal
control subjects. Target stimulus probability was varied
systematically (0.20, 0.50, 0.80) in different task
conditions. No differences between the CFS and control
subjects were found for either P3 amplitude or latency. No
group effects were observed for the N1, P2, and N2 components.
Despite the attentional and immediate memory deficits reported
in CFS, the P3 ERP from auditory stimuli does not reliably
discriminate CFS from matched control subjects.

Polich J, Moore AP, Wiederhold MD

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