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PACE-GATE: An alternative view on a study with a poor trial protocol

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By B. Stouten
 
Abstract
 
The controversies surrounding the effectiveness of cognitive behavioural therapy and graded exercise therapy for chronic fatigue syndrome are explained using Cohen’s d effect sizes rather than arbitrary thresholds for ‘success’. This article shows that the treatment effects vanish when switching to objective outcomes. The preference for subjective outcomes by the PACE trial team leads to false hope. This article provides a more realistic view, which will help patients and their doctors to evaluate the pros and cons.

Source: Stouten B. PACE-GATE: An alternative view on a study with a poor trial protocol. J Health Psychol. 2017 Aug;22(9):1192-1197. doi: 10.1177/1359105317707531. Epub 2017 May 12.

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