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parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.

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Abstract

We have isolated in vitro fluoroquinolone-resistant mutants of the
Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

Antimicrob Agents Chemother. 2005 Oct;49(10):4354-7. Comparative Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, Non-P.H.S.; Research Support, U.S. Gov’t, P.H.S.

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