The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline for one month, commencing during the early (3 weeks) or chronic (4 months) stages of infection with Borrelia burgdorferi.
Tissues from mice were tested for infection by culture, polymerase chain reaction (PCR), xenodiagnosis, and transplantation of allografts at 1 and 3 months after completion of treatment. In addition, tissues were examined for spirochetes by immunohistochemistry.
In contrast to saline-treated mice:
Results indicated that following antibiotic treatment:
Source: Antimicrobial Agents and Chemotherapy, March 3, 2008. [E-pub ahead of print] PMID: 18316520, by Hodzic E, Feng S, Holden K, Freet KJ, Barthold SW. Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, USA. [E-mail: Stephen Barthold firstname.lastname@example.org ]