Pharmacological treatment of Fibromyalgia and other chronic musculoskeletal pain

[Note: Dr. Don Goldenberg is a widely recognized pioneer and leader in medical research for the treatment of FM.]

Journal: Best Practice and Research Clinical Rheumatology. 2007 Jun;21(3):499-511.

Author and affiliation: Goldenberg DL. Newton-Wellesley Hospital, Division of Rheumatology, Newton, Massachusetts, USA.

PMID: 17602996

The pharmacologic management of Fibromyalgia is based on the emerging evidence that pain in this disorder is primarily related to central pain sensitization.

There is strong evidence that tricyclic antidepressants are effective, and moderate evidence for the effectiveness of serotonin reuptake inhibitors and dual serotonin-norepinephrine reuptake inhibitors.

Recent work suggests that the anti-seizure medications pregabalin [LyricaR, the first drug approved by the FDA for treatment of Fibromyalgia] and gabepentin are also effective.

The only analgesic demonstrated to be helpful is tramadol.

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