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Pharmacology of pain processing systems

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Integration of nociceptive signaling comprises peripheral,

spinal, and supraspinal sites of the nervous system. Various

excitatory or inhibitory neurotransmitter and–modulator

systems participate in pain processing and modulation. Chronic

pain states are associated with functional and structural

alterations of nociceptive pathways. The numerous dynamic

changes in the pharmacologically distinct systems offer novel

targets for selective pharmacotherapy.

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