Possible joint origin of restless leg syndrome (RLS) and migraine

Journal: Medical Hypotheses. 2007 Jan 25; [E-publication ahead of print] Authors and affiliation: Sabayan B, Bagheri M, Borhani Haghighi A. Student Research Committee, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. PMID: 17258401

Sleep disorders have been described in migraine patients. Among sleep disorders RLS has been reported in up to one-third of migraineurs. Adverse effects of anti migraine therapy by dopamine antagonists can not fully explain this association. Therefore we present the hypothesis that RLS and migraine may have a joint origin. The hypothesis is supported by:
1. The same genetic origin for migraine without aura and RLS in single Italian family on chromosome 14q21; this gene codes survival motor neuron-interacting protein 1 (SIP1) which can play role in both diseases.
2. Correlation of both RLS and migraine with Fibromyalgia.
3. Alteration of cortical excitability in both migraine and RLS.

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