Prevalence of human herpesvirus 6 variants A & B in patients with Chronic Fatigue Syndrome (CFS)

Peripheral blood mononuclear cells collected from 13 patients with

chronic fatigue syndrome and 13 healthy controls were analyzed

for the presence of human herpesvirus 6 (HHV-6) DNA by

variant-specific polymerase chain reaction and dot blot

hybridization. HHV-6 DNA was detected in 7 of 13 (53%)

patients, and of those 7 patients, 4 were positive for HHV-6

variant A DNA and 3 were for variant B. No HHV-6 DNA was

detected in the controls. Serum antibody titers to the late

antigen and antibody prevalence to the early antigen of HHV-6

were significantly higher in the patient group.

These results suggest active replication of HHV-6 in

patients with chronic fatigue syndrome.

Yalcin S, Kuratsune H, Yamaguchi K, Kitani T, Yamanishi K

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