Peripheral blood mononuclear cells collected from 13 patients with
chronic fatigue syndrome and 13 healthy controls were analyzed
for the presence of human herpesvirus 6 (HHV-6) DNA by
variant-specific polymerase chain reaction and dot blot
hybridization. HHV-6 DNA was detected in 7 of 13 (53%)
patients, and of those 7 patients, 4 were positive for HHV-6
variant A DNA and 3 were for variant B. No HHV-6 DNA was
detected in the controls. Serum antibody titers to the late
antigen and antibody prevalence to the early antigen of HHV-6
were significantly higher in the patient group.
These results suggest active replication of HHV-6 in
patients with chronic fatigue syndrome.
Yalcin S, Kuratsune H, Yamaguchi K, Kitani T, Yamanishi K