Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in patients with Chronic Fatigue Syndrome (CFS)

To evaluate the association between human herpesvirus 6 (HHV-6) and
chronic fatigue syndrome (CFS), 2 geographically separate
groups of CFS patients (125 and 29 patients, respectively) and
healthy controls (150 and 15 controls, respectively) were
compared, using an EIA, for antibodies to HHV-6 early antigen
p41/38 (EA). Sixty percent (93/154) of CFS patients were were
positive for HHV-6 EA IgM, 40% (61/154) were positive for IgG,
and 23% (35/154) were positive for both. A total of 119 (77%)
of the CFS patients were positive for HHV-6 EA IgG or IgM (or
both); only 12% (20/165) of the controls had IgG or IgM to
HHV-6 EA. These data demonstrate that more CFS patients than
controls had elevated levels of HHV-6 EA-specific IgM, perhaps
indicating active replication of HHV-6 in CFS.

Patnaik M, Komaroff AL, Conley E, Ojo-Amaize EA, Peter JB

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