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This study determined the prevalence of
Lyme meningitis in children with undifferentiated aseptic meningitis from April to December in a
Lyme disease-endemic region. Of the 60 children, 8 were seropositive (prevalence 13.3%; 95% confidence interval: 6.3-25.1%), with another probable case having high cerebrospinal fluid antibody titers. Clinicians in endemic regions should evaluate children with undifferentiated aseptic meningitis for
Lyme meningitis in appropriate seasons.