The Wall Street Journal’s chronic fatigue syndrome tracker, Amy Dockser Marcus, reported Feb 17 on new XMRV research published Feb 16 in the Journal of Virology (“Infection, viral dissemination and antibody reponses of Rhesus macaques exposed to the human gammaretrovirus,” by Onlamoon N, et al.)
As Dockser Marcus reports in her neat summary (see “XMRV: Study Shows Virus Can Cause ‘Persistent Infection’ in Monkeys”), this research involving intravenously infected macaque monkeys found that though the early signs of infection in the animals’ blood* had disappeared fairly quickly, autopsies later found XMRV infected cells in their GI tract lining, prostate, lungs, and spleen. She also reports on the authors' views regarding the implications, issues raised, and their plans for follow-up research.
As their article abstract concludes: "Our findings establish a nonhuman primate model to study XMRV replication/dissemination, transmission, pathogenesis, immune responses, and potential future therapies."
* See the earlier report published Aug 17, 2010 in Retrovirology – “Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies.”