10% Off $75 Orders! Use Code SAVE10P Shop Now
One use per customer. Not available with Autoship. Expires 5/28/18.

Protection of synapses against Alzheimer’s-linked toxins: Insulin signaling prevents the pathogenic binding of amyloid beta oligomers – Source: Proceedings of the National Academy of Sciences, Feb 10, 2009

1 Star2 Stars3 Stars4 Stars5 Stars (20 votes, average: 3.00 out of 5)
Loading...

[To read the full text of this article free,
click here
]

Synapse deterioration underlying severe memory loss in early Alzheimer’s disease (AD) is thought to be caused by soluble amyloid beta (AB) oligomers.

Mechanistically, soluble AB oligomers, also referred to as AB-derived diffusible ligands (ADDLs), act as highly specific pathogenic ligands, binding to sites localized at particular synapses. This binding triggers oxidative stress, loss of synaptic spines, and ectopic redistribution of receptors critical to plasticity and memory.

We report here the existence of a protective mechanism that naturally shields synapses against ADDL-induced deterioration.

Synapse pathology was investigated in mature cultures of hippocampal neurons. Before spine loss, ADDLs caused major downregulation of plasma membrane insulin receptors (IRs), via a mechanism sensitive to calcium calmodulin-dependent kinase II (CaMKII) and casein kinase II (CK2) inhibition.

• Most significantly, this loss of surface IRs, and ADDL-induced oxidative stress and synaptic spine deterioration, could be completely prevented by insulin.

• At submaximal insulin doses, protection was potentiated by rosiglitazone, an insulin-sensitizing drug used to treat type 2 diabetes.

• The mechanism of insulin protection entailed a marked reduction in pathogenic ADDL binding.

• Surprisingly, insulin failed to block ADDL binding when IR tyrosine kinase activity was inhibited; in fact, a significant increase in binding was caused by IR inhibition.

The protective role of insulin thus derives from IR signaling-dependent downregulation of ADDL binding sites rather than ligand competition.

The finding that synapse vulnerability to ADDLs can be mitigated by insulin suggests that bolstering brain insulin signaling, which can decline with aging and diabetes, could have significant potential to slow or deter AD pathogenesis.

Source: Proceedings of the National Academy of Sciences, Feb 10, 2009;106(6):1971-6. PMID: 19188609, by De Felice F, Vieira MNN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST, Klein WL. Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, USA; Instituto de Bioquímica Médica and Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. [E-mail: wklein@northwestern.edu or felice@bioqmed.ufrj.br]

1 Star2 Stars3 Stars4 Stars5 Stars (20 votes, average: 3.00 out of 5)
Loading...



Leave a Reply