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Rapid clearance of Lyme disease spirochetes lacking OspC from skin.

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Abstract

We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.

Infect Immun. 2007 Mar;75(3):1517-9. Epub 2006 Dec 11. Research Support, N.I.H., Intramural

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