Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism.

The treatment of Alzheimer’s disease remains a major challenge because of our incomplete understanding of the triggering events that lead to the selective neurodegeneration characteristic of Alzheimer’s brains. The rational design of a pharmacological intervention is therefore a great theoretical challenge.

One approach involves the study of the pharmacological modulation of the amyloid precursor protein metabolism, in which the goal is to reduce the formation of beta-amyloid in the hope of reducing the formation of a potentially neurotoxic peptide. Such an approach has led to the identification of a complex intracellular mechanism that can be regulated by neurotransmitters and other ligands.

Source: Trends Pharmacol Sci 1999 Oct;20(10):418-423

PMID: 10498955

(Institute of Pharmacology, University of Pavia, Viale Taramelli 14 27100 Pavia, Italy.)

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