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Reactogenicity and immunogenicity of a Lyme disease vaccine in children 2-5 years old.

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Abstract

Two doses of a recombinant
Lyme disease vaccine (15 and 30 microg) were administered to children 2-5 years old (0-1-month schedule) and were well tolerated. Both doses were highly immunogenic with geometric mean titers 1 month after vaccination of 4366 and 9877 ELISA units (EU)/mL, respectively. Nearly all subjects had antibody levels of > or = 1400 EU/mL, suggesting protective tick titre for one tick season.

Clin Infect Dis. 2000 Dec;31(6):1504-7. Clinical Trial; Clinical Trial, Phase II

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