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Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome

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Note: You can read the full article HERE.
 
By Marta Pozuelo et al.
 
Abstract
 
The pathophysiology of irritable bowel syndrome (IBS) remains unclear. Here we investigated the microbiome of a large cohort of patients to identify specific signatures for IBS subtypes.
 
We examined the microbiome of 113 patients with IBS and 66 healthy controls. A subset of these participants provided two samples one month apart. We analyzed a total of 273 fecal samples, generating more than 20 million 16S rRNA sequences.
 
In patients with IBS, a significantly lower microbial diversity was associated with a lower relative abundance of butyrate-producing bacteria (P?=?0.002; q?<?0.06), in particular in patients with IBS-D and IBS-M. IBS patients who did not receive any treatment harboured a lower abundance of Methanobacteria compared to healthy controls (P?=?0.005; q?=?0.05). Furthermore, significant correlations were observed between several bacterial taxa and sensation of flatulence and abdominal pain (P?<?0.05).
 
Altogether, our findings showed that IBS-M and IBS-D patients are characterized by a reduction of butyrate producing bacteria, known to improve intestinal barrier function, and a reduction of methane producing microorganisms a major mechanism of hydrogen disposal in the human colon, which could explain excess of abdominal gas in IBS.
 
Source: Marta Pozuelo, Suchita Panda, Alba Santiago, Sara Mendez, Anna Accarino, Javier Santos, Francisco Guarner, Fernando Azpiroz & Chaysavanh Manichanh. Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome. Scientific Reports 5, Article number: 12693 doi:10.1038/srep12693. Published 04 August 2015

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