Results of Blood Group Susceptibility Survey in Chronic Fatigue Syndrome and a New Hypothesis on Blood Platelets (Thrombocytes)

Jed Gallagher (

A total of 36 CFS/ME patients sent data to me on their blood group, sinusitis and upper palate shape.

1) 75% Rhesus Positive – 25% Rhesus Negative – no significant difference to general population.

2) Blood groups – no significant differences to general population.

3) Non-allergic Sinusitis – 81% prevalence.

This is an extremely sigificant marker for CFS/ME – but it is still a secondary symptom. Given that research had shown non-allergic rhinitus is present in all CFS/ME patients – rhinitis (bacterial?) is probably the cause of the sinusitis (bacterial?).

4) 89% of those with a V-shaped upper palate also have sinusitis – while only 72% of those with a C-shaped upper palate also have sinusitis.

This is consistent with evidence that people with a V-shaped palate are more likely to develop sinusitis – due to anatomical reduction of the nasal space.


The lack of any correlation between blood group/type and CFS/ME appears to rule this out as a susceptibility factor.

However, research has shown that blood group antibodies have a protective function against blood infection. In one paper, anti-A group antibodies were shown to have an anti-staphylococcal (coagulase negative) function.

More significant to blood infection susceptibility in CFS/ME could be the dysfunction of blood platelets (thrombocytes). Platelets have the same blood group typing as red blood cells – a genetic trait.

In the CFS/ME paper below, blood platelets correlated negatively with red and white blood cell profiles in CFS/ME patients but positively with controls:

Immunological and Haematological Parameters in Patients with Chronic Fatigue Syndrome / T K Roberts. Journal of Chronic Fatigue Syndrome (1998) 4(4):51-65.

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