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Resveratrol May Support Weight Loss by Mobilizing Fat-Discouraging Gene Expression, Research Suggests

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Article Title
Changes in white adipose tissue metabolism induced by resveratrol in rats – Source: Nutrition and Metabolism, May 10, 2011

By G Alberdi, MT Macarulla, et al.

[To read the complete article, now available as a provisional PDF, click HERE. It cites more than 30 studies relating to resveratrol’s effect on fat formation & matabolism.]

Article Abstract

Background: A remarkable range of biological functions have been ascribed to resveratrol. Recently, this polyphenol has been shown to have body fat lowering effects. The aim of the present study was to assess some of the potential underlying mechanisms of action which take place in adipose tissue.

Methods: Sixteen male Sprague-Dawley rats were randomly divided into two groups: control and treated with 30 mg resveratrol per kg body weight daily. All rats were fed an obesogenic [fat-producing] diet and after six weeks of treatment white adipose [fat] tissues were dissected.

Lipoprotein lipase activity was assessed by fluorimetry, acetyl-CoA carboxylase by radiometry, and malic enzyme, glucose-6P-dehydrogenase and fatty acid synthase by spectrophotometry. Gene expression levels of acetyl-CoA carboxylase, fatty acid synthase, lipoprotein lipase, hormone-sensitive lipase, adipose triglyceride lipase, PPAR-gamma, SREBP-1c and perilipin were assessed by Real time RT-PCR. The amount of resveratrol metabolites in adipose tissue was measured by chromatography.

Results:

• There was no difference in the final body weight of the rats;

• However, adipose [fat] tissues were significantly decreased in the resveratrol-treated group.

Resveratrol reduced the activity of lipogenic enzymes, as well as that of heparin-releaseable lipoprotein lipase. Moreover, a significant reduction was induced by this polyphenol in hormone-sensitive lipase mRNA levels.

No significant changes were observed in other genes. Total amount of resveratrol metabolites in adipose tissue was 2.66+/-0.55 nmol/g tissue.

Conclusions: It can be proposed that the body fat-lowering effect of resveratrol is mediated, at least in part, by a reduction in fatty acid uptake from circulating triacylglycerols and also in de novo lipogenesis.

Source: Nutrition and Metabolism, May 10, 2011. By Alberdi G, Rodriguez VM, Miranda J, Macarulla MT, Arias N, Adres-Lacueva C, Protillo MP. Department of Nutrition and Food Science, Faculty of Pharmacy, University of País Vasco, Vitoria; Instituto de Salud Carlos III, Madrid; Department of Nutrition and Food Science, XaRTA, INSA, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain. INGENIO-CONSOLIDER Program, Ministry of Science and Innovation, Barcelona, Spain. [E-mail: mariateresa.macarulla@ehu.es]

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