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Resveratrol supplementation improves arterial stiffness in type 2 diabetics

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Reprinted with the kind permission of Life Extension.

August 18 2017. A randomized, double-blind study reported on August 3, 2017 in the International Heart journal found improvements in arterial stiffness and oxidative stress among type 2 diabetics who were supplemented with resveratrol.

The trial included 50 diabetic men and women who received 100 milligrams resveratrol or a placebo daily for 12 weeks. Cardio-ankle vascular index (CAVI, a novel diagnostic measure of arterial stiffness that is a marker of atherosclerosis) and blood pressure were assessed at the beginning and end of the study, in addition to blood assessments of oxidative stress and other factors.

At the end of the study, subjects who received resveratrol had significantly lower blood pressure, less oxidative stress and decreased arterial stiffness in comparison with values obtained at the beginning of the study.  Participants who received a placebo experienced no significant changes in these areas.
“The primary finding in the present study was that oral supplementation of resveratrol for 12 weeks decreased CAVI in patients with type 2 diabetes mellitus,” authors Haruki Imamura, MD, and colleagues at Toho University Sakura Medical Center in Japan write. “Many previous studies have demonstrated increased CAVI in atherosclerotic diseases such as acute coronary syndrome and stroke, and these reports indicate that CAVI reflects organic atherosclerosis.”
They suggest that a reduction in oxidative stress may be one mechanism involved in the improvement in arterial stiffness observed in this study among participants who received resveratrol. Improved endothelial function via increased nitric oxide production may be another mechanism.

“Resveratrol may be beneficial in preventing the development of atherosclerosis induced by diabetes,” the authors conclude. “However, a large-scale cohort study is required to validate the present findings.”

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