Salivary cortisol profiles in Chronic Fatigue Syndrome (CFS)

Salivary cortisol profiles (hourly sampling over a 16-hour period)

of 10 patients with chronic fatigue syndrome (CFS) but without

concurrent depressive disorder were compared with those of 10

healthy volunteers matched for age, sex and menstrual cycle.

The mean saliva cortisol concentration over the 16-hour period

was slightly but significantly greater in the patients than

the controls (p < 0.05). These findings are at variance with

earlier reports that CFS is a hypocortisolaemic state and

suggest that in CFS the symptom of fatigue is not caused by


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