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Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin.

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Recombinant (r) outer surface proteins (Osp) A and B, flagellin, and an immunogenic region of flagellin (41-G) from Borrelia burgdorferi were evaluated using immunoblot and ELISA for usefulness as substrates in diagnostic testing for
Lyme disease. Antibodies to rOspA, rOspB, and r-flagellin were detected by immunoblot and ELISA using the recombinant proteins. Patients with late
disease responded to rOspA, rOspB, and r-flagellin, or only to r-flagellin, whereas patients with early
disease showed no response or responded only to r-flagellin. Patients who developed antibodies to r-flagellin also responded to 41-G. The data suggest that recombinant B. burgdorferi antigens can serve as substrates for immunoblot and ELISA, which may be helpful in diagnosing
Lyme disease.

J Infect Dis. 1992 Jun;165(6):1127-32. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.

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