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Seroprevalence of anti-Borrelia antibodies among patients with confirmed sarcoidosis in a region of Japan where Lyme borreliosis is endemic.

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Sarcoidosis is a multisystemic granulomatous
disease of unknown etiology, while
Lyme borreliosis is a multisystemic disorder caused by Borrelia burgdorferi. The purpose of this study is to evaluate the relationship between sarcoidosis and
Lyme borreliosis in a region of Japan where
Lyme borreliosis is endemic.


We determined the seroprevalence of anti-Borrelia burgdorferi antibodies as well as antibodies three Japanese Borrelia strains by enzyme-linked immunosorbent assay and dotblot assay using purified Borrelia-specific proteins in 46 patients with confirmed sarcoidosis and 150 controls (50
disease controls and 100 healthy controls) in Hokkaido, the affected region.


Fifteen patients with sarcoidosis (32.6%) tested positive for Borrelia spirochete in both assays, compared with two
disease controls (4.0%) and two healthy controls (2.0%). The seroprevalence of anti-Borrelia antibodies in patients with sarcoidosis was much higher in the affected region than in the region in our previous study were
Lyme borreliosis is non-endemic.


In a region where
Lyme borreliosis is endemic, Borrelia infection may be partially associated with sarcoidosis.

Graefes Arch Clin Exp Ophthalmol. 1998 Apr;236(4):280-4. Comparative Study; Research Support, Non-U.S. Gov’t

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