Serum cholesterol, APOE genotype, and the risk of Alzheimer’s disease: a population-based study of African Americans

SUMMARY: A link was found between cholesterol levels and Alzheimer’s in this population. The results suggest that this “modifiable risk factor” may be a possible treatment.

Evans RM, Emsley CL, Gao S, Sahota A, Hall KS, Farlow MR, Hendrie H. Neurology 2000 Jan 11;54(1):240-2. Department of Neurology, Indiana University School of Medicine, Indianapolis 46202-5111, USA.

A significant interaction among total serum cholesterol (TC), APOE genotype, and AD risk was found in a population-based study of elderly African Americans. Increasing TC was associated with increased AD risk in the group with no epsilon4 alleles, whereas TC was not associated with increased AD risk in the group with one or more epsilon4 alleles. Further study of the relationship between cholesterol and APOE genotype is needed to confirm this association, but the results suggest that cholesterol may be a potentially modifiable environmental risk factor for AD.

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