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Serum complement sensitivity as a key factor in Lyme disease ecology.

Abstract

The sensitivity of Borrelia burgdorferi sensu lato to animal sera was analyzed. Complement-mediated borreliacidal effects were observed with particular combinations of host serum and Borrelia genospecies. The species-specific pattern of viability and/or lysis is highly consistent with the pattern of reservoir competence of hosts for B. burgdorferi sensu lato, suggesting a key role of complement in the global ecology of
Lyme borreliosis.

Infect Immun. 1998 Mar;66(3):1248-51. [1]